团队队伍

微生物学与免疫学系

孙栋

日期:2022-02-09 点击数: 来源:

 

孙栋

 

姓名: 孙栋
职称: 副教授
最高学位: 博士
电话: 18844569967
Email: dongsun@jlu.edu.cn
工作地点: 生命科学楼409室

 

研究方向:

课题组利用小鼠为模式生物,结合化学遗传方法,脑立体定位注射,环路示踪,行为学测试,高通量测序,细胞及分子生物学等技术手段研究神经疾病(焦虑障碍,抑郁症等)发生的分子机制。

教育经历:

2017/11–2021/03,   Case Western Reserve University(美国),   博士后               
2012/09–2017/07,   东北师范大学,皇冠官方手机端官网,            博士
2015/11–2016/11,   Augusta University(美国),            国家公派联合培养博士
2008/09–2012/07,   东北师范大学,皇冠官方手机端官网,            学士

工作经历:

2021/09–至今,          公司,皇冠官方手机端官网,                副教授

荣誉称号:
研究成果: 1. Dong Sun#, Zhi-Bing Tan#, Xiang-Dong Sun, Zhi-Peng Liu, Wen-Bing Chen, Leena Milibari, Xiao Ren, Ling-Ling Yao, Daehoon Lee, Chen Shen, Jin-Xiu Pan, Zhi-Hui Huang, Lin Mei, and Wen-Cheng Xiong*. (2021) Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response. PNAS  https://doi.org/10.1073/pnas.2022921118  
2. Dong Sun, Leena Milibari, Jin-Xiu Pan, Xiao Ren, Ling-Ling Yao, Yang Zhao, Chen Shen, Wen-Bing Chen, Fu-Lei Tang, Daehoon Lee, Jun-Shi Zhang, Lin Mei, Wen-Cheng Xiong*. (2021) Critical roles of embryonic born dorsal dentate granule neurons for activity-dependent increases in BDNF, adult hippocampal neurogenesis, and anti-anxiety-like behaviors. Biological Psychiatry DOI: https://doi.org/10.1016/j.biopsych.2020.08.026
3. Dong Sun, Xiang-Dong Sun, Lu Zhao, Dae-Hoon Lee, Jin-Xia Hu, Fu-Lei Tang, Jin-Xiu Pan, Lin Mei, Xiao-Juan Zhu*, Wen-Cheng Xiong*. (2018) Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior. Cell Death & Disease DOI: 10.1038/s41419-017-0019-2
4.  Jin-Xiu Pan#, Dong Sun#, Daehoon Lee, Lei Xiong, Xiao Ren, Hao-han Guo, Ling-ling Yao, Yuyi Lu, Caroline Jung, Wen-Cheng Xiong*. (2021) Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence. Communications Biology DOI: https://doi.org/10.1038/s42003-021-02843-2 (#, equal contribution)
5. Xiang-Dong Sun#*, Wen-Bing Chen#, Dong Sun#, Jie Huang, Yuan-Quan Li, Jin-Xiu Pan, Ya-Nan Wang, Kai Zhao, Zhao-Qi Dong, Hong-Sheng Wang, Lei Xiong, Aiguo Xuan, Shen-Ting Zhao, Anilkumar Pillai, Wen-Cheng Xiong* and Lin Mei. (2018) Neogenin in Amygdala for Neuronal Activity and Information Processing. The Journal of Neuroscience 38(44):0433-18 (#, equal contribution)
6. Dong Sun, Xue Zhou, Hua-Li Yu, Xiao-Xiao He, Wei-Xiang Guo, Wen-Cheng Xiong*, Xiao-Juan Zhu*. (2017) Regulation of neural stem cell proliferation and differentiation by Kinesin family member 2a. PLoS ONE DOI: 10.1371/journal.pone.0179047
7. Wen-bing Chen#, Bin Luo#, Nan-nan Gao#, Hai-wen Li, Hong-sheng Wang, Lei Li, Wan-peng Cui, Lei Zhang, Dong Sun, Fang Liu, Zhao-qi Dong, Xiao Ren, Hong-sheng Zhang, Hua-bo Su, Wen-Cheng Xiong, Lin Mei*. (2021) Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models. The Journal of Clinical Investigation DOI: 10.1172/JCI136956  
8. Ling-ling Yao#, Jin-xia Hu#, Qiang Li#, Daehoon Lee, Xiao Ren, Jun-shi Zhang, Dong Sun, Hong-sheng Zhang, Yong-gang Wang, Lin Mei, and Wen-Cheng Xiong*. (2020) Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex. The Journal of Clinical Investigation DOI: 10.1172/JCI132372
9.  Fu-Lei Tang, Lu Zhao, Yang Zhao, Dong Sun, Xiao-Juan Zhu, Lin Mei, Wen-Cheng Xiong*. (2020) Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons. Cell Death & Differentiation 27, pages2099–2116(2020)
10. Hua-Li Yu#, Yun Peng#, Yang Zhao, Yong-Sheng Lan, Bo Wang, Lu Zhao, Dong Sun, Jin-Xiu Pan, Zhao-Qi Dong, Lin Mei, Yu-Qiang Ding, Xiao-Juan Zhu* and Wen-Cheng Xiong*. (2020) Myosin X interaction with KIF13B, a crucial pathway for Netrin-1-induced axonal development. The Journal of Neuroscience DOI: https://doi.org/10.1523/JNEUROSCI.0929-20.2020
11. Sen Lin#, Wei Liu#, Chun-Lin Chen#, Dong Sun, Jin-Xia Hu, Lei Li, Jian Ye, Lin Mei, Wen-Cheng Xiong*. (2019) Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation. Journal of Molecular Cell Biology, Volume 12, Issue 1, January 2020, Pages 17–31
12. Bo Wang, Jin‐Xiu Pan, Huali Yu, Lei Xiong, Kai Zhao, Shan Xiong, Jun‐Peng Guo, Sen Lin, Dong Sun, Lu Zhao, Haohan Guo, Lin Mei, Wen‐Cheng Xiong*. (2019) Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast‐Lineage Cells. Journal of Bone and Mineral Research https://doi.org/10.1002/jbmr.3667
13. Jin-Xiu Pan, Lei Xiong, Kai Zhao, Peng Zeng, Bo Wang, Fu-Lei Tang, Dong Sun, Hao-han Guo, Xiao Yang, Shun Cui, Wen-Fang Xia, Lin Mei, Wen-Cheng Xiong*. (2018) YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling. Bone Research DOI: 10.1038/s41413-018-0018-7
14. Joanna Ruth Appel, Shi-yang Ye, Fu-lei Tang, Dong Sun, Hong-sheng Zhang, Lin Mei and Wen-Cheng Xiong*. (2018) Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice. The Journal of Neuroscience 38(26):3621-17
15. Xin-Chun Ye#, Jin-Xia Hu#, Lei Li, Qiang Li, Fu-Lei Tang, Sen Lin, Dong Sun, Xiang-Dong Sun, Gui-Yun Cui, Lin Mei, Wen-Cheng Xiong*. (2017) Astrocytic Lrp4 (Low-Density Lipoprotein Receptor–Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A2AR (Adenosine A2A Receptor) Signaling. Stroke 49(1):STROKEAHA.117.018115
16. Zhihui Huang, Dong Sun, Jin-Xia Hu, Fu-Lei Tang, Dae-Hoon Lee, Ying Wang, Guoqing Hu, Xiao-Juan Zhu, Jiliang Zhou, Lin Mei and Wen-Cheng Xiong*. (2016) Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. The Journal of Neuroscience 36(21):5833-5849
17. Huali Yu, Dong Sun, Nannan Wang, Min Wang, Yongsheng Lan, Wenqiang Fan, Yang Zhao, Weixiang Guo*, Xiaojuan Zhu*. (2015) Headless Myo10 is a regulator of microtubule stability during neuronal development. Journal of Neurochemistry DOI: 10.1111/jnc.13238
18. Hengliang Shi#, Chunling Fu#, Wei Wang, Yu Li, Shuang Du, Rangjuan Cao, Jingying Chen, Dong Sun, Zhongyu Zhang, Xingzhi Wang, Xiaojuan Zhu*. (2014) The FGF‐1‐specific single‐chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. Journal of Cellular and Molecular Medicine DOI: 10.1111/jcmm.12371
19. Huali Yu, Nannan Wang, Xingda Ju, Yan Yang, Dong Sun, Mingming Lai, Lei Cui, Muhammad Abid Sheikh, Jianhua Zhang, Xingzhi Wang*, Xiaojuan Zhu*. (2012) PtdIns (3,4,5) P3 Recruitment of Myo10 Is Essential for Axon Development. PLoS ONE DOI: 10.1371/journal.pone.0036988