团队队伍

细胞生物学与生物物理学系

王丽萍

日期:2020-08-11 点击数: 来源:

      名:

王丽萍

 

      称:

教授

最高学位:

博士研究生

    话:

0431-85155348

      件:

wanglp@jlu.edu.cn

工作地点:

生命科学楼552

研究方向

小分子多功能肽的研究与开发;功能抗体的设计、表达及临床应用研究;过氧化物模拟酶的设计及应用研究

 

教育经历:

1985.9-1990.7,公司分子生物学系,生物化学,本科
  1990.9-1993.7
,公司分子生物学系,生物化学,硕士
  1996.9-1999.7
,皇冠官方手机端官网(中国)有限公司,生物化学,博士

工作经历:

1993.9-1995.9, 公司分子生物学系 助教
  1995.9-1999.12
, 公司分子生物学系 讲师
  2000.1-2005.9
,皇冠官方手机端官网(中国)有限公司,副教授
  2005.10-
至今, 皇冠官方手机端官网(中国)有限公司,教授

荣誉称号:

获得2011-2013年度公司巾帼建功标兵

研究成果

1. 基础理论基因工程肽库和蛋白质分子间识别规律研究蛋白质结构、功能和蛋白质工程研究
 
以基因工程肽库为主要手段,筛选目的物的配体,揭示目的物与配体之间的特异识别规律。该项研究不仅在理论上有重要意义,而且也是新药筛选和设计的有利手段。
  2.
新药筛选和生物技术制药的研究
 
开展生物活性肽类药物的研究,本课题是以基因工程肽库为主要工具,筛选出具有生理活性的小肽类药物。在此基础上,作为负责人承担两项吉林省科技厅的课题治疗II型糖尿病的药物的临床前研究,并与长春大政药业有限公司正在开展治疗脑卒中的国家一类新药的研发。
  3.
纳米材料在生物学领域的应用
 
量子点在生物学领域的应用;低维金属纳米材料应用于肿瘤热疗方面等研究,金银纳米红外光敏材料应用于癌症靶向治疗2007年获得了科技部863项目子课题的资助;
  5.
与多家企业合作进行产学研方面的研发,主要承担课题有:“NTX特异性核酸适配子的筛选辣椒提取物的研究开发提高辣椒红色素稳定性抗氧化剂的研发新木地区管道设备腐蚀与防护技术研究抗氧化/抗衰老线虫评价方法的研究肉灵芝的人工培育及功效研究等。
 
指导多名硕士研究生和博士生的毕业论文。在国内外学术刊物上发表论文60余篇,获得专利授权12项,申请专利保护10余项。

代表性论文:

1.   Ye Yuan, Zhendong Fu , Kai Wang , Zhenyu Zhao , Hui Li , Zhi   Wang * and Liping Wang *, Design and characterization of a   hypersensitive glucose sensor : two enzymes co-fixed on a copper phosphate   skeleton, Journal of Materials   Chemistry B,   2020, 8, 244 -250.( IF5.344)

2. Yi Ding, Zhiying Li, Wei   Jiang, Bolei Yuan, Tingting Huang, Liping Wang*, Jun Tang*. Degradation of phenol using a   peroxidase mimetic catalyst through conjugating deuterohemin-peptide onto   metalorganic framework with enhanced catalytic activity, Catalysis   Communications, 2020,134:   105859.(IF 3.612)

3. Kai Wang , Yuting Liang, Yu   Su and Liping Wang*. DhHP-6   Ameliorates Hepatic Oxidative Stress and Insulin Resistance in Type 2   Diabetes Mellitus Through the PI3K/AKT and AMPK Pathway. Biochem J. 2020,477(12):2363-2381(IF 4.097)

4. Kai Wang, Yanhui Song, Yu Su , Yuting Liang, Liping   Wang*.   Effect of the   hairpin structure of peptide inhibitors on the blockade of PD-1/PD-L1 axis. Biochem Biophys Res   Commun.2020,   527 (2):   453-457.( IF 2.985)

5. Ye Yuan,Liping Wang, Lizeng Gao. Nano-Sized Iron   Sulfide: Structure, Synthesis, Properties, and Biomedical Applications. Front.   Chem., 2020,00818(IF 3.693)

6.   Jia Xu, Ye Yuan, Ruining Zhang, Yanhui Song, Tianzhuo Sui, Jiaqi Wang,   Chonghan Wang, Yujia   Chen, Shuwen Guan, Liping Wang*. A deuterohemin peptide protects a transgenic Caenorhabditis   elegans model of Alzheimer’s disease by inhibiting Aβ1–42 aggregation. Bioorganic   Chemistry.  82 (2019) 332–339. (IF 3.88)

7. Ye Yuan, Jia Xu, Zhenyu Zhao, Hui Li,   Kai Wang, Zhi Wang,* and Liping Wang*, Design and 8. Characterization of a   Novel Artificial Peroxidase, Catalysts 2019, 9, 168-172 (IF   3.58)

Kai Wang  , Yu Su, Yuting Liang,   Yanhui Song  and Liping Wang *, Oral DhHP-6 for the Treatment of Type 2   Diabetes Mellitus. Int. J. Mol. Sci. 2019, 20, 1517-1523.(IF   4.32)

9. Han W,   Yuan Y, Li H, Fu Z, Wang M, Guan S, Wang L. Design and anti-tumor activity of self-loaded   nanocarriers of siRNA. Colloids Surf B   Biointerfaces. 2019,183: 110385-110393(IF 4.11)

10.   Jia Xu, Kai Wang, Ye Yuan, Hui Li,   Ruining Zhang, Shuwen Guan  and Liping   Wang *  A Novel Peroxidase Mimics and Ameliorates Alzheimer’s   Disease-Related Pathology and Cognitive Decline in Mice. Int. J. Mol. Sci. 2018,   19, 11:3304-3341 (IF4.187)

11. Xu J,Guo Y,Sui T,Wang Q,Zhang Y,Zhang R,Wang M,Guan S,Wang L. Molecular Mechanisms of Anti-oxidant and   Anti-aging Effects Induced by Convallatoxin in Caenorhabditis elegans.Free Radic Res.201751529-544.(IF3.188)

12. Tianshu Xu, Tianlei Ying,   Lili Wang, Xiaohua Doug,Ying Wang, Lishan Kang, Tao Huang, Liang Cheng,   Liping Wang* and Qi Zhao.   A native-like bispecific antibody suppresses the inflammatory   cytokine response by simultaneously neutralizing tumor necrosis factor-alpha   and interleukin-17A, Oncotarget, 2017, 8(47):81860-81872   (IF5.168)

13.Zhi-Ming Xiu, Li-Ping Wang, Jun Fu,   Jia Xu, Li Liu, 1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: an aldose reductase   inhibitor for the treatment of diabetic nephropathy, Bioorganic   &Medicinal ChemistryLetters,2017   27(18):4482-4487(IF 2.454)

14. Wei, Ying; Lu, Jun; Lu, Tong; Meng,   Feihong; Xu, Jia; Wang, Li; Li, Yang; Wang, Liping*; Li, Fei.   Formation of lamellar micelle-like oligomers and membrane disruption revealed   by the study of short peptide hIAPP(18-27). PHYSICAL CHEMISTRY CHEMICAL   PHYSICS, 2016, 18:29847-29857.(IF4.449)

15. Zhao, Zijian; Zhang, Ji; Wang,   Mingyang; Wang, Zhi; Wang, Liping; Ma, Li; Huang, Xuri; Li,   Zhengqiang. Structure advantage and peroxidase activity enhancement of   deuterohemin-peptide-inorganic hybrid flowers. RSC ADVANCES, 2016,   6:104265-104272. (IF3.119)

16. Zhao, Zijian; Wang, Dandan; Wang,   Mingyang; Sun, Xiaoli; Wang, Liping; Huang, Xuri; Ma, Li; Li,   Zhengqiang. Proximal environment controlling the reactivity between inorganic   sulfide and heme-peptide model. RSC ADVANCES, 2016, 6:78858-78864. (IF3.119)

17. Guo, Changrun; Goodwin, Andrew;   Buie, Joy N. Jones; Cook, James; Halushka, Perry; Argraves, Kelley;   Zingarelli, Basilia; Zhang, Xian; Wang, Liping; Fan, Hongkuan.   A Stromal Cell-Derived Factor 1 alpha Analogue Improves Endothelial Cell   Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.MOLECULAR   MEDICINE, 2016, 22:1512-1524.IF3.53

代表性专利:

1.       王丽萍,李惟,关树文,徐佳,张越,三价铁卟啉及其衍生物-短肽化合物和三价铁卟啉及其衍生物-短肽化合物的应用,201710543121.4, 授权日2020.9.18

2.     王丽萍;修志明;付君;徐佳,APPA在制备治疗糖尿病肾病药物中的应用, 2016106561742, 授权日2019.4.2

3.     一种次血红素二肽及其制备方法和用途, 王丽萍,修志明,于欣冉,李惟.2014106494842, 授权日,2017.7.26